| Akronim | Penjelasan |
| S |
| S | [kimia] Sulfur or Sulphur (Sulfur). |
| S/N | Signal-to-Noise (ratio). |
| S&T | Science and Technology (Sains dan Teknologi). |
| S-VHS | Super Video Home System. |
| SA | State Assemblyman (Ahli Dewan Undangan Negeri). |
| SAC | Syariah Advisory Council. |
| SADCs | State Agriculture Development Corporations. |
| SAGA | Standard Accounting system for Government Agencies. |
| SALCRA | SArawak Land Consolidation and Rehabilitation Authority. |
| SALM | Malaysian Farm Accreditation Scheme (Skim Akreditasi Ladang Malaysia). |
| SALT | Livestock Farm Accreditation Scheme (Skim Akreditasi Ladang Ternakan). |
| SAM | Surface-to-Air Missile. |
| SAP | [tidak rasmi] Seat Again Please. |
| SARS | Severe Acute Respiratory Syndrome (Sindrom Pernafasan Akut Yang Teruk). |
| Sas. | Kesusasteraan (Literature). |
| s.a.w. | [Arab] sallAllahu 'alaihi wa-sallam. |
| SB | Seni Bina, Shaw Brothers. |
| Sb | [kimia] Stibium (id est Antimony) (Stibium atau Antimoni). |
| Sb. | Sabah. |
| SBA | Sekuriti Bersandarkan Aset (Asset-Backed Securities). |
| SBB | Sistem Binaan Berindustri (Industrialised Building System). |
| sbg. | sebagai (as). |
| SBK | Syarikat Berkaitan Kerajaan (Government-Linked Companies). |
| SC | Securities Commission (Suruhanjaya Sekuriti). |
| Sc | [kimia] Scandium (Skandium). |
| SCA | Securities Commission Act 1993AD (Akta Suruhanjaya Sekuriti 1993AD). |
| SCADA | Supervisory Control And Data Acquisition. |
| SCANS | Securities Clearing Automated Network Services. |
| SCSI | Small Computer Systems Interface. |
| SCuM | [tidak rasmi] soc.culture.malaysia (newsgroup). |
| SDCs | Skills Development Centres. |
| Sdn. Bhd. | Sendirian Berhad (Private Limited). |
| sdr. | saudari. |
| SDRC | Small Debt Resolution Committee (Jawatankuasa Penyelesaian Hutang Kecil). |
| Se | [kimia] Selenium (Selenium). |
| SEATO | South East Asia Treaty Organization (Pertubuhan Pakatan Asia Tenggara). |
| SEB | Sabah Electricity Board (Lembaga Letrik Sabah). |
| SECAM | SEquentiel Couleur Avec Memoire (television system). |
| SEDCs | State Economic Development Corporations. |
| SEFF | Small Entrepreneur Financing Fund. |
| Sej. | Sejarah (History). |
| SEMS | Stock Exchange of Malaysia and Singapore. |
| Sep. | September (September). |
| Sept. | September (September). |
| SESB | Sabah Electricity Sendirian Berhad. |
| SESCo | Sarawak Electricity Supply Corporation. |
| s.f. | short form (kependekan). |
| Sg | [kimia] Seaborgium (Siborgium). |
| SGPCA | Skim Geran Penunjuk Cara Aplikasi (Demonstrator Applications Grant Scheme). |
| SGPPI | Skim Geran Penyelidikan dan Pembangunan Industri (Industry Research and Development Grant Scheme). |
| SGPPKRM | Skim Geran Penyelidikan dan Pembangunan Koridor Raya Multimedia (Multimedia Super Corridor Research and Development Grant Scheme). |
| SGX | SinGapore eXchange (Bursa Singapura). |
| Si | [kimia] Silicon (Silikon). |
| Si. | Singapura. |
| SIA 1983 | Securities Industry Act 1983AD (Akta Perindustrian Sekuriti 1983AD). |
| SIC | Spelling InCorrect. |
| SIM | Standard Institution of Malaysia (Pusat Piawaian Malaysia). |
| SING | [tidak rasmi] Singapore (dollar). |
| SIRIM | Standards and Industrial Research Institute of Malaysia (Institut Piawaian dan Penyelidikan Perindustrian Malaysia). |
| SITTDEC | South Investment, Trade, and Technology Data Exchange Centre. |
| sj. | sejenis (a type of). |
| SKDTP | Sindrom Kurang Daya Tahan Penyakit (Acquired Immuno-Deficiency Syndrome). |
| SKM | Sekuriti Kerajaan Malaysia, Sijil Kelayakan Menduduki (Certificate of Fitness for Occupation), Sijil Kemahiran Malaysia. |
| SKSM | Skim Kemahiran Semula Graduan (Graduate Re-skilling Scheme). |
| SL | Seni Lukis. |
| Sl. | Selangor. |
| sl. | sastera lama (classical literature). |
| SLMCH | (Special) Scheme for Low-and-Medium Cost Houses. |
| SLR | Single Lens Reflex (camera). |
| SM | Sebelum Masehi (Before Christ), Syarikat Multinasional (Multinational Companies/Corporations). |
| Sm | [kimia] Samarium (Samarium). |
| SMART | Stormwater Management And Road Tunnelling (Terowong Pengurusan Banjir dan Lalulintas Kenderaan). |
| SMEs | Small and Medium-scale/sized Enterprises. |
| SMEt | State Mineral Enactment. |
| SMIs | Small and Medium-scale/sized Industries. |
| SMIDEC | Small and Medium Industries DEvelopment Corporation (Perbadanan Pembangunan Industri Kecil dan Sederhana). |
| SMIDP | Small and Medium Industry Development Plan. |
| SMJK | Sekolah Menengah Jenis Kebangsaan (National Type Secondary School). |
| SMR | Standard Malaysian Rubber (Getah Mutu Malaysia). |
| SMS | Sarjana Muda Sains (Bachelor of Science), Sarjana Muda Sastera (Bachelor of Arts), Short Message Services (Khidmat Pesanan Pendek). |
| SMT | Syarikat Modal Teroka. |
| SMTP | Simple Mail Transfer Protocol. |
| SN | Sains Nuklear (Nuclear Science), Serial Number. |
| Sn | [kimia] Stannum (id est Tin) (Stanum atau Timah). |
| SOB | Son Of (a) Bitch. |
| SOCSO | SOCial Security Organization. |
| SOHO | Small Office or Home Office. |
| Son. | [kitab injil] Song of Solomon/Songs (Kidung Agung). |
| SOS | Save Our Souls (international standard distress call). |
| Sos. | Sosiologi (Sociology). |
| SP | Sijil Prestasi, Syarat-syarat Penyenaraian (Listing Requirements). |
| SPA | Suruhanjaya Perkhidmatan Awam. |
| SPAM | Syarikat Perdagangan Antarabangsa Malaysia (Malaysian International Trading Companies). |
| SPCA | Society for the Prevention of Cruelty to Animals. |
| SPKR | Skim Pembangunan Kesejahteraan Rakyat. |
| SPLAM | Skim PersijiLan Akuakultur Malaysia (Malaysian Aquaculture Farm Certification Scheme). |
| SPM | Sijil Pelajaran Malaysia, Sistem Penerbangan Malaysia (Malaysia Airlines System). |
| SPNB | Syarikat Perumahan Negara Berhad. |
| SPSP | Skim Pilihan Saham Pekerja (Employee Share Option Schemes). |
| spt. | seperti (as...as). |
| Sr | [kimia] Strontium (Strontium). |
| Sr. | Sarawak. |
| sr. | seruan (exclamation). |
| SRJK | Sekolah Rendah Jenis Kebangsaan (National Type Primary School). |
| SRP | Sijil Rendah Pelajaran. |
| SRR | Statutory Reserve Requirement. |
| SS | Sungei Way Subang. |
| SSM | Sistem Saraan Malaysia, Suruhanjaya Syarikat Malaysia (Companies Commission of Malaysia). |
| STD | Sexually Transmitted Disease. |
| STEP2 | Second Science and Technology Policy. |
| STIC | Strategic Thrusts Implementation Committee. |
| STKB | Skim Tarif Keutamaan Berkesan (Common Effective Preferential Tariff). |
| STP | Sijil Tinggi Pelajaran. |
| STS | Secondary Technical Schools. |
| SU | SetiaUsaha. |
| Suk. | Sukan (Sports). |
| SVGA | Super Video Graphics Array. |
| SVS | Secondary Vocational Schools. |
| SW | Shortwave (radio). |
| SWAT | Special Weapons And Tactics (police team). |
| SWF | Single White Female. |
| s.w.t. | [Arab] subhanahu wa ta'ala. |
| Sykt. | Syarikat. |
