| Akronim | Penjelasan |
| U |
| U | [kimia] Uranium (Uranium). |
| Ubat | Perubatan (Medicine). |
| UDA | Urban Development Authority (Lembaga Pembangunan Bandar). |
| Udg. | Undang-undang (Law). |
| UFO | Unidentified Flying Object. |
| UH | University Hospital. |
| UIA | Universiti Islam Antarabangsa (International Islamic University). |
| UiTM | Universiti Teknologi MARA. |
| UK | [tidak rasmi] Ulu Klang, United Kingdom. |
| UKM | Universiti Kebangsaan Malaysia (National University of Malaysia). |
| UL | Underwriters Laboratories. |
| Ul. | [kitab injil] Ulangan (Deuteronomy). |
| ULC | Unit Labour Cost (Kos Unit Buruh). |
| UM | University Malaya. |
| UMNO | United Malays National Organisation (Pertubuhan Kebangsaan Melayu Bersatu), [tidak rasmi] yoU Must Not Object. |
| UMS | Universiti Malaysia Sabah. |
| UN | United Nations. |
| UN/OSCAL | United Nations Office of the Special Coordinator for Africa and the Least (Developed Countries). |
| UNCLE | United Network Command for Law Enforcement. |
| UNCTAD | United Nations Conference on Trade And Development (Persidangan Bangsa-bangsa Bersatu berkenaan Perdagangan dan Pembangunan). |
| UNDP | United Nations Development Programme. |
| UNESCO | United Nations Educational, Scientific, and Cultural Organization (Pertubuhan Pendidikan, Saintifik, dan Kebudayaan Pertubuhan Bangsa-bangsa Bersatu). |
| UNFCCC | United Nations Framework Convention on Climate Change. |
| UNFPA | United Nations Fund for Population Activities. |
| UNHCR | United Nations High Commissioner for Refugees. |
| UNICEF | United Nations International Children's Emergency Fund. |
| UNIMAS | UNIversiti MAlaysia Sarawak. |
| UNTAET | United Nations Transitional Administration in East Timor. |
| UPE | Unit Perancang Ekonomi. |
| UPM | Universiti Pertanian Malaysia, Universiti Putra Malaysia (Putra University of Malaysia). |
| UPS | Uninterruptible Power Supply, United Parcel Service. |
| UPSR | Ujian Penilaian Sekolah Rendah. |
| URL | Uniform Resource Locator. |
| US | United States. |
| USAINS | USAINS Group of Companies (Kumpulan Syarikat USAINS). |
| USD | United States Dollar (Dolar Amerika Syarikat). |
| USM | Universiti Sains Malaysia (Science University of Malaysia). |
| USNO | United Sabah National Organization (Persatuan Kebangsaan Sabah Bersatu). |
| USS | United States Ship. |
| USSR | Union of Soviet Socialist Republics (now Russia). |
| UTC | Universal Time Coordinated. |
| UTF | Unit Trust Fund (Amanah Saham Nasional). |
| utk. | untuk (for). |
| UTM | Universiti Teknologi Malaysia (Technology University of Malaysia). |
